Located in the swamps of Haiti is Mz. Ruby, the Fiendish Five's chief mystic who was originally plotting to take over the world using ghosts. Mz. Ruby comes from a family of mystics, and possesed special powers. However, those special powers led to a childhood of loneliness, as other children feared Mz. Ruby. This caused Mz. Ruby to become very bitter, and as a result, she set on a mission to make the world regret making her feel like an outcast. This made Mz. Ruby decide to isolate herself in thr jungles of Haiti, only surrounded by those that she controlled with her voodoo.
Of course, being a member of the Fiendish Five meant that Mz. Ruby also had stolen part of the Thievius Raccoonus, causing Sly and the gang set out to confront her. The Cooper Gang encounter various obstacles in attempt to reach Mz. Ruby, including many ghosts, spiders, and swamp monsters. This army of ghosts was created by Mz. Ruby herself, using her knowledge of voodoo.